Ultrasonic Drug Uncaging and Neuromodulation

Aryal M*, Azadian MM*, Hart AR, Macedo N, Zhou Q, Rosenthal, EL, Airan RD. Noninvasive ultrasonic induction of cerebrospinal fluid flow enhances intrathecal drug delivery. Journal of Controlled Release. 2022 Jun 30; 349:434-442. doi: 10.1016/j.jconrel.2022.06.067. PubMED PMID: 35798095

Wang JB*, Di Ianni T*, Vyas DB, Huang Z, Park S, Hosseini-Nassab N, Aryal M, Airan RD. Focused ultrasound for noninvasive, focal pharmacologic neurointervention. Frontiers in Neuroscience. 2020 Jul 14;14:675. doi: 10.3389/fnins.2020.00675. PubMED PMID: 32760238

Zhong Q*, Yoon BC*, Aryal M, Wang JB, Ilovitsh T, Baikoghli MA, Hosseini-Nassab N, Karthik A, Cheng RH, Ferrara KW, Airan RD. Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters. Biomaterials. 2019 Jun; 206:73-86. doi: 10.1016/j.biomaterials.2019.03.021. PubMed PMID: 30953907

Wang JB*, Aryal M*, Zhong Q, Vyas D, Airan RD. Noninvasive Ultrasonic Drug Uncaging Maps Whole-Brain Networks. Neuron. 2018 Nov 7;100(3):728-738.e7. doi: 10.1016/j.neuron.2018.10.042.PubMed PMID: 30408444

Airan RD, Butts Pauly K. Hearing out Ultrasound Neuromodulation. Neuron. 2018 Jun 6;98(5):875-877. doi: 10.1016/j.neuron.2018.05.031. PubMed PMID: 29879389

Airan RD.  Neuromodulation with Nanoparticles. Science. 2017 Aug 4. 357(6350):465. doi: 10.1126/science.aao1200. PubMed PMID: 28774921

Airan RD, Meyer RA, Ellens NP, Rhodes KR, Farahani K, Pomper MG, Kadam SD, Green JJ. Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions. Nano Lett.2017 Feb 8;17(2):652-659. doi: 10.1021/acs.nanolett.6b03517. PubMed PMID: 28094959


Zhang F, Tsai HC, Airan RD, Stuber GD, Adamantidis AR, de Lecea L, Bonci A, Deisseroth K. Optogenetics in Freely Moving Mammals: Dopamine and Reward. Cold Spring Harb Protoc. 2015 Aug 3;2015(8):715-24. doi: 10.1101/pdb.top086330. PubMed PMID: 26240415.

Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC, Deisseroth K. Natural neural projection dynamics underlying social behavior. Cell. 2014 Jun 19;157(7):1535-51. doi: 10.1016/j.cell.2014.05.017. PubMed PMID: 24949967; PubMed Central PMCID: PMC4123133.

Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 2010 Mar;5(3):439-56. doi: 10.1038/nprot.2009.226. PubMed PMID: 20203662; PubMed Central PMCID: PMC4503465.

Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature. 2009 Apr 23;458(7241):1025-9. doi: 10.1038/nature07926. PubMed PMID: 19295515.

Hu ES, Airan RD, Vijaykumar R, Deisseroth K. Brain circuit dynamics. Am J Psychiatry. 2008 Jul;165(7):800. doi: 10.1176/appi.ajp.2008.08050764. PubMed PMID: 18593784.

Airan RD, Hu ES, Vijaykumar R, Roy M, Meltzer LA, Deisseroth K. Integration of light-controlled neuronal firing and fast circuit imaging. Curr Opin Neurobiol. 2007 Oct;17(5):587-92. Review. PubMed PMID: 18093822.

Molecular Imaging

Airan RD, Foss CA, Ellens NP, Wang Y, Mease RC, Farahani K, Pomper MG. MR-Guided Delivery of Hydrophilic Molecular Imaging Agents Across the Blood-Brain Barrier Through Focused Ultrasound. Mol Imaging Biol. 2017 Feb;19(1):24-30. [Epub ahead of print] PubMed PMID: 27481359.

Song X, Airan RD, Arifin DR, Bar-Shir A, Kadayakkara DK, Liu G, Gilad AA, van Zijl PC, McMahon MT, Bulte JW. Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells. Nat Commun. 2015 Mar 27;6:6719. doi: 10.1038/ncomms7719. PubMed PMID: 25813863; PubMed Central PMCID: PMC4380237.

Airan RD, Li N, Gilad AA, Pelled G. Genetic tools to manipulate MRI contrast. NMR Biomed. 2013 Jul;26(7):803-9. doi: 10.1002/nbm.2907. Review. PubMed PMID: 23355411; PubMed Central PMCID: PMC3669659.

Airan RD, Bar-Shir A, Liu G, Pelled G, McMahon MT, van Zijl PC, Bulte JW, Gilad AA. MRI biosensor for protein kinase A encoded by a single synthetic gene. Magn Reson Med. 2012 Dec;68(6):1919-23. doi: 10.1002/mrm.24483. PubMed PMID: 23023588; PubMed Central PMCID: PMC3504643.

Functional Brain Imaging

Di Ianni T, Airan RD. Deep-fUS: A deep learning platform for functional ultrasound imaging of the brain using sparse data. IEEE transactions on medical imaging. 2022 Feb 2;41(7):1813-25. doi: 10.1109/TMI.2022.3148728. PubMed PMID: 35108201

Tian Q, Wintermark M, Jeffrey Elias W, Ghanouni P, Halpern CH, Henderson JM, Huss DS, Goubran M, Thaler C, Airan R, Zeineh M, Pauly KB, McNab JA. Diffusion MRI tractography for improved transcranial MRI-guided focused ultrasound thalamotomy targeting for essential tremor. Neuroimage Clin. 2018 May 9;19:572-580. doi: 10.1016/j.nicl.2018.05.010. PubMed PMID: 29984165

Yahyavi-Firouz-Abadi N, Pillai JJ, Lindquist MA, Calhoun VD, Agarwal S, Airan RD, Caffo B, Gujar SK, Sair HI. Presurgical Brain Mapping of the Ventral Somatomotor Network in Patients with Brain Tumors Using Resting-State fMRI. AJNR Am J Neuroradiol. 2017 May;38(5):1006-1012. doi: 10.3174/ajnr.A5132. Epub 2017 Mar 31. PubMed PMID: 28364005

Pereira L, Airan RD, Fishman A, Pillai JJ, Kansal K, Onyike CU, Prince JL, Ying SH, Sair HI. Resting-state functional connectivity and cognitive dysfunction correlations in spinocerebelellar ataxia type 6 (SCA6). Hum Brain Mapp. 2017 Jun;38(6):3001-3010. doi: 10.1002/hbm.23568. Epub 2017 Mar 15. PubMed PMID: 28295805

Airan RD, Vogelstein JT, Pillai JJ, Caffo B, Pekar JJ, Sair HI. Factors affecting characterization and localization of interindividual differences in functional connectivity using MRI. Hum Brain Mapp. 2016 May;37(5):1986-97. doi: 10.1002/hbm.23150. PubMed PMID: 27012314.

Agarwal S, Sair HI, Airan RD, Hua J, Jones CK, Heo HY, Olivi A, Lindquist MA, Pekar JJ, Pillai JJ. Demonstration of Brain Tumor-Induced Neurovascular Uncoupling in Resting-State fMRI at Ultrahigh Field. Brain Connect. 2016 May;6(4):267-72. doi: 10.1089/brain.2015.0402. PubMed PMID: 26918887; PubMed Central PMCID: PMC4876542.

Sair HI, Yahyavi-Firouz-Abadi N, Calhoun VD, Airan RD, Agarwal S, Intrapiromkul J, Choe AS, Gujar SK, Caffo B, Lindquist MA, Pillai JJ. Presurgical brain mapping of the language network in patients with brain tumors using resting-state fMRI: Comparison with task fMRI. Hum Brain Mapp. 2016 Mar;37(3):913-23. doi: 10.1002/hbm.23075. PubMed PMID: 26663615.

Agarwal S, Sair HI, Yahyavi-Firouz-Abadi N, Airan R, Pillai JJ. Neurovascular uncoupling in resting state fMRI demonstrated in patients with primary brain gliomas. J Magn Reson Imaging. 2016 Mar;43(3):620-6. doi: 10.1002/jmri.25012. PubMed PMID: 26201672.

Yue C, Chen S, Sair HI, Airan R, Caffo BS. Estimating a graphical intra-class correlation coefficient (GICC) using multivariate probit-linear mixed models. Comput Stat Data Anal. 2015 Sep;89:126-133. PubMed PMID: 26190878; PubMed Central PMCID: PMC4501040.

Coughlin JM, Wang Y, Munro CA, Ma S, Yue C, Chen S, Airan R, Kim PK, Adams AV, Garcia C, Higgs C, Sair HI, Sawa A, Smith G, Lyketsos CG, Caffo B, Kassiou M, Guilarte TR, Pomper MG. Neuroinflammation and brain atrophy in former NFL players: An in vivo multimodal imaging pilot study. Neurobiol Dis. 2015 Feb;74:58-65. doi: 10.1016/j.nbd.2014.10.019. PubMed PMID: 25447235; PubMed Central PMCID: PMC4411636.

Lim IA, Faria AV, Li X, Hsu JT, Airan RD, Mori S, van Zijl PC. Human brain atlas for automated region of interest selection in quantitative susceptibility mapping: application to determine iron content in deep gray matter structures. Neuroimage. 2013 Nov 15;82:449-69. doi: 10.1016/j.neuroimage.2013.05.127. PubMed PMID: 23769915; PubMed Central PMCID: PMC3966481.

Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science. 2007 Aug 10;317(5839):819-23. PubMed PMID: 17615305.

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